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KMID : 1161220210640090480
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Clinical and Experimental Pediatrics
2021 Volume.64 No. 9 p.480 ~ p.488
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Cohort profile: National Investigation of Birth Cohort in Korea study 2008 (NICKs-2008)
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Kim Ju-Hee
Lee Jung-Eun
Shim So-Min
Ha Eun-Kyo
Yon Dong-Keon
Kim Ok-Hyang
Baek Ji-Hyeon
Koh Hyun-Yong
Chae Kyu-Young
Lee Seung-Won
Han Man-Yong
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Abstract
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Background: An adequate large-scale pediatric cohort based on nationwide administrative data is lacking in Korea.
Purpose: This study established the National Investigation of Birth Cohort in Korea study 2008 (NICKs-2008) based on data from a nationwide population-based health screening program and data on healthcare utilization for children.
Methods: The NICKs-2008 study consisted of the Korean National Health Insurance System (NHIS) and the National Health Screening Program for Infants and Children (NHSPIC) databases comprising children born in 2008 (n=469,248) and 2009 (n=448,459) in the Republic of Korea. The NHIS database contains data on age, sex, residential area, income, healthcare utilization (International Classification of Diseases-10 codes, procedure codes, and drug classification codes), and healthcare providers. The NHSPIC consists of 7 screening rounds. These screening sessions comprised physical examination, developmental screening (rounds 2?7), a general health questionnaire, and age-specific anticipatory guidance.
Results: During the 10-year follow-up, 2,718 children (0.3%) died, including more boys than girls (hazard ratio, 1.145; P<0.001). A total of 848,048 children participated in at least 1 of the 7 rounds of the NHSPIC, while 96,046 participated in all 7 screening programs. A total of 823 infants (0.1%) weighed less than 1,000 g, 3,177 (0.4%) weighed 1,000?1,499 g, 37,166 (4.4%) weighed 1,500?2,499 g, 773,081 (91.4%) weighed 2,500?4,000 g, and 32,016 (5.1%) weighed over 4,000 g. There were 23,404 premature babies (5.5%) in 2008 compared to 23,368 (5.6%) in 2009. The developmental screening test indicated appropriate development in 95%?98% of children, follow-up requirements for 1%?4% of children, and recommendations for further evaluation for 1% of children.
Conclusion: The NICKs-2008, which integrates data from the NHIS and NHSPIC databases, can be used to analyze disease onset prior to hospitalization based on information such as lifestyle, eating habits, and risk factors.
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KEYWORD
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Cohort profile, National cohort, Infant, Child, Health screening
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